Job offers

Postdoctoral researcher to work on Chaperone-Mediated Autophagy (CMA) (scholarship)

One postdoctoral position is available in the Laboratory of Helin V. Norberg, research group on Protein Degradation Pathways at the Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, Stockholm, Sweden.

Chaperone-mediated autophagy (CMA) is a selective protein degradation process. By studying this pathway, our previous studies uncovered that CMA can selectively be directed to target oncoproteins (proteins involved in the onset or development of cancers). (Hao et al., Autophagy, 2019; Xia et al., JCB 2015) or by specific targeting to UPS (Eriksson et al., MCB, 2017; Zhang et al., Cell Reports, 2017). Currently, we are investigating the CMA pathway in depths both at cellular and organismal level, in order to explore the intriguing possible role of CMA in various human cancers. The applicant will conduct research within the field of molecular cancer research with a focus on protein degradation pathways.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate.

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Requirements

We seek dedicated, highly motivated and hardworking individual with previous experience in cell and molecular biology as well as biochemistry.

The candidate must have a Ph.D. in Medical Sciences or related discipline(s). We seek a candidate who have experience with cancer research and possess a strong background in cancer biology. Candidates with extensive and documented experience in tumor biology, cellular protein degradation pathways are urged to apply. Candidates that possess previous work and publications on autophagy, chaperone-mediated autophagy and the Ubiquitin proteasome system (UPS) are favorable.

The candidate must be willing to work ambitiously and effectively in a collaborative environment with a strong commitment to research. The successful candidate must have strong organizational skills with the ability to manage several projects simultaneously. A great ability to express themselves in speech and writing, including scientific writing in advanced level of English are required. The candidate´s personal skills will be highly valued and emphasis will be placed on personal skills, knowledge and abilities, as well as on documented previous work.

Application process

Employment applications should be sent to helin.norberg@ki.se. An employment application must contain the following documents:

  • A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work with a complete list of publications
  • A short summary of current work (max one page)
  • Reference letters and contacts

Postdoctoral position available in Vojo Deretic’s group

A postdoctoral position is available in Vojo Deretic’s (https://en.wikipedia.org/wiki/Vojo_Deretic) group at the NIH-funded AIM center (https://www.autophagy.center/). The AIM center is a biomedical research excellence center for autophagy, inflammation and metabolism at the University of New Mexico, Albuquerque, USA; see editorial in Autophagy, 2018, 14, 925-929. Dr. Deretic’s group is working on autophagy in fundamental and disease contexts in mammalian and human cells and animal models. The position is to work on intersections between organellar membrane homeostasis, autophagy response to membrane damage, and will involve studies on metabolism and secretory autophagy as well. Details of the project can be glimpsed form the published studies, for example Jia et al., Molecular Cell  2018, 70, 120-135. Please contact Dr. Deretic directly by email (vderetic@salud.unm.edu) to explore possibilities and further details.

Postdoc position – Regenerative Medicine Center Utrecht

Profile
We are looking for an enthusiastic, highly motivated candidate with a strong interest in a molecular understanding of biology. We are especially interested in applicants that are excited to work in a collaborative and multidisciplinary environment and have solid background in cell and molecular biology.

Project

The project aims to characterize the molecular mechanisms underlying the anti-inflammatory and regenerative properties of MSC-derived extracellular vesicles (MSC-EVs) in cartilage repair. The research is a follow up of our work showing that MSC-EVs are an important component of MSC paracrine signalling and have a major contribution to cartilage regeneration and inhibition of inflammatory responses in osteoarthritic chondrocytes.

You will be working with the variety of techniques including: differential centrifugation and sucrose gradient, size exclusion chromatography, Western blotting, flow cytometry, cell culture, confocal microscopy, electron microscopy, nanoparticle tracking analysis, cutting edge cloning techniques, lentiviral transductions, making transgenic cell lines, co-culture, siRNA knock down and Crispr-Cas9 technology. The project will also make use of the unique material from osteoarthritic patients.

Organization

You will be working at the Regenerative Medicine Center in Utrecht, which offers an international, very dynamic and stimulating work environment. The RMCU is an inter-faculty initiative with scientists from medicine and veterinary medicine gathered together. This provides a unique collaborative setting for regenerative medicine projects. The RMCU houses the world-class equipment and is located in the scientific campus of the Utrecht University with the access to a large number of facilities. Utrecht is beautiful city located in the center of the Netherlands, in close proximity of Amsterdam and its international airport.

Application deadline: 28 February 2019

Application process: Please send one PDF document containing a cover letter with your motivations, a very concise summary of previous research activities, the curriculum vitae and the contact details for 3 referees to m.j.lorenowicz@umcutrecht.nl

Further information: For more information on the research focus of the group please check our website. For questions about the position, please send an email to m.j.lorenowicz@umcutrecht.nl

15 PhD positions are available in the field of Autophagy around Europe

Positions in Finland, France, Germany, Israel, Netherlands, Norway, Spain, and United Kingdom

DRIVE (Driving next generation autophagy researchers towards translation) is a Marie Skłodowska-Curie Action (MSCA), Innovative Training Network (ITN) H2020-MSCA-ITN-2017, funded by the European Commission under Grant Agreement n. 765912.

Eligibility (who can apply): Early-Stage Researchers (ESRs).

Application: eligible candidates should fill in the application form and upload a cover letter stating their motivation and research interests, an updated CV with the dates of relevant diplomas (day, month and year), and the contact information of 2 referee persons.

Applicants should apply to their preferred research team within DRIVE’s network (click here for details), but they can indicate a secondary and tertiary preference in their application.