1 PhD position (group led by group leader L. Frankel, Denmark)
The Frankel group is seeking a highly motivated and ambitious PhD student to join us at the Danish Cancer Institute. Our research group comprises a young, international, collaborative team that investigates how dysregulation of cellular homeostasis contributes to tumorigenesis. In doing so, we seek in-depth molecular understanding of cellular stress-response mechanisms including autophagy, protein aggregation and proteasome signaling, with the aim of exploiting our knowledge for new therapeutic strategies in the clinic.
The PhD project
The successful candidate will join an exciting project focused on revealing and characterizing the molecular regulation of autophagy and its contribution to tumor development and progression. Specifically, the project will focus on new roles for ubiquitin signaling enzymes and ubiquitin-related control of selected substrate degradation by autophagy. The project combines the use of state-of-the-art microscopy, biochemical assays, CRISPR-Cas9 genome editing, RNA sequencing, proteomics and bioinformatics. Importantly, the candidate will work broadly with cellular models, combining these with in vivo mouse models and analysis of patient-derived material, to bridge the in vitro mechanistic analyses to a patient-near context. Our work is interdisciplinary and involves a strong network of national and international collaborators. Within the group we value a cooperative and friendly atmosphere, and the successful candidate will work in collaboration with other group members.
Start: January 2024