WIA (Women in Autophagy) 3rd Technical workshop: Inducers and inhibitors of autophagy
Next October 6th, WIA network organizes the 3rd Technical workshop, about Inducers and inhibitors of autophagy. Registration is free of charge for WIA members (becoming a WIA member is easy and free of charge).
14:10-14:55: David Rubinsztein: “P97 and autophagosome biogenesis"
14:55-15:40: Carmine Settembre: ”Manipulating and monitoring selective autophagy in vivo”
16:00-16:45: Mericka McCabe: “Design and Development of Selective Chaperone-mediated Autophagy (CMA) Activators"
16:45-17:30: Nikolai Engedal: ”Exploring autophagic inducers and inhibitors with cargo-based autophagy assays”
17:30-18:30: General discussion
BNMI (Bridging Nordic Microscopy Infrastructures)
Bridging Nordic Microscopy Infrastructure (BNMI) is a network of national imaging infrastructures offering open access to biological imaging technologies in participating Nordic countries.
The inaugural BNMI symposium will be held between 17th and 19th of August. The event focuses on the use and development of imaging in life science research in the Nordic countries. The symposium schedule includes current research discussions, presentations on novel technologies, and showcasing the Nordic infrastructures. Participants will connect with fellow scientists, thus expanding their networks. The event takes place at the University of Iceland, in Reykjavík.
BNMI Is also offering a mobility program for young scientists and core facility staff, and we incourage you to apply
Apsana Lamsal (Lab Exchange Grantee)
Does arginine starvation induce selective or bulk autophagy?
Host: Dr. Nikolai Engedal (Oslo University Hospital)
Duration of visit: 4 weeks (Nov 22nd to Dec 17th, 2021)
Cancer cells can alter the Tumor Microenvironment by several mechanisms. They can have altered metabolism and recruit immunosuppressive cells, such as myeloid derived suppressor cells (MDSCs) or neutrophil-like cells, which can secrete arginase-1 (ARG1). We had observed a close link between ARG1 expression and reduced arginine in breast cancer tumors. We therefore hypothesized that local arginine depletion induces autophagy in the tumor. We observed arginine starvation was a strong signal for induction of selective autophagy receptors in breast cancer cells. So, we wanted to know if arginine starvation induces selective or bulk autophagy. To understand this, a lab visit to Dr. Nikolai Engedal’s group was arranged for measuring cytosolic cargo sequestration using the Lactate Dehydrogenase Sequestration (LDH) Assay. This assay allows quantitative measurement of autophagic sequestration of the endogenous cytosolic cargo protein lactate dehydrogenase. The assay was used with success during my stay and already provided some interesting results. In collaboration with Dr Engedal’s lab, we also made mKeima-based reporter cell lines. This further allows us to understand if arginine starvation induces only bulk autophagy, or also selective autophagy of mitochondria. From the very first day to the last, I had a pleasant lab visit with a very good lab environment and the visit was a great success. We will maintain an active collaboration with Dr. Nikolai Engedal. I thank NAS for providing me this opportunity.
Autophagy Reports (new journal)
Publish Diamond in Autophagy Reports
Co-Editors Daniel J Klionsky and Fulvio Reggiori are excited to announce the launch of a new open access sister journal to Autophagy, introducing Autophagy Reports.
Benefiting from the same publishing team of well-established journal Autophagy, to celebrate this exciting introduction all accepted papers will be published open access free of charge in 2022!
Autophagy Reports is a peer reviewed, open access journal publishing research on all aspects of autophagic processes.
The aim of Autophagy Reports is the rapid communication of high quality, novel research, which takes a multidisciplinary overview on the fundamental, translational and/or clinical aspects connected to autophagic processes.
Autophagy Reports covers the following topics: autophagic processes (i.e., the lysosome/vacuole-dependent degradation of intracellular material); the connections between autophagy and various aspects of human health and disease including cancer, neurodegeneration, aging, diabetes, myopathies and heart disease. We are interested in all experimental systems, from yeast to plant and human. Suggestions for appropriate specialized topics are welcome.
The journal accepts the following article types:
- Original research (basic science, translational and clinical)
- Reviews and Mini Reviews
- Brief Reports/Rapid Communications
- Technical papers (toolbox, protocol and resource)
- Commentaries and Views
For more information and to submit your manuscript:
4th NORDIC AUTOPHAGY SOCIETY CONFERENCE / 9th NORDIC AUTOPHAGY MEETING – TROMSØ 2021
The 4th Nordic Autophagy Society (NAS) Conference / 9th Nordic Autophagy Meeting was held in Tromsø, Norway November 10th-12th 2021. This was the first Nordic Autophagy Meeting north of the Arctic Circle! Due to the Covid-19 pandemic, the Conference had been postponed for nearly 1 ½ years. It had originally been scheduled for June 2020.
Held at the Edge Hotel directly at the Tromsø harbor with a great view of the city and the surrounding arctic landscape, the Conference featured a record-breaking 109 participants coming from 15 different countries. Covid-19 measures were in place, with facemasks worn during mingling. The scientific program comprised 4 Invited Keynote Lectures, 14 Selected Short Talks, and 2 Poster Sessions with in total 48 Poster Presentations. See here for the program.
The Conference was opened by a Keynote from Ian Ganley (University of Dundee, UK), who gave an inspiring talk on mitophagy and its links to Parkinson’s disease. This was followed by an introduction from the Silver Sponsor and Exhibitor Nordic BioSite, and thereafter 5 selected short talks, which commonly were focused on molecular mechanisms of mitophagy and selective autophagy in general.
An engaging Poster session 1 (for 1 ½ hours) was held in the afternoon, before dinner at the hotel.
After the dinner, although the sky was generally cloudy, a few fortunate people (no names disclosed) managed to see Northern Lights right outside the hotel!
Part 1: The second day of the Conference was kicked off by Nicholas Ktistakis (Babraham Institute, Cambridge, UK), who presented beautiful and thought-provoking visual data to compare and contrast the mechanisms of autophagosome formation in nonselective versus selective autophagy. Furthermore, a taste from a new, unpublished project was presented. Thereafter followed 4 selected short talks that covered mechanisms, regulation and coordination of autophagy in mammalian cells and yeast.
Part 2: After lunch it was time for the social program. Some went for a city walk to include sights like the bridge and the famous Arctic Cathedral. Others took a guided tour with the cable car to the top of the Fløya mountain. The toughest (or craziest?) participants bought spikes for their shoes (or not!) and heroically climbed the 1203 Sherpa steps (iced and slippery!) to reach the same destination. From there, both parties could enjoy a stunning view over Tromsø and the surrounding arctic landscape, just in time before sunset. All totally worth it!
Part 3: The next scientific session featured the 3rd Keynote lecture, where Marja Jäättelä (Danish Cancer Society Research Center, Denmark) provided an engaging overview of the multifaceted cellular functions of lysosomes and presented novel data on effects of cationic amphiphilic drugs via lysosomes. Thereafter followed 2 short talks on aspects related to the connection between autophagy, lysosomes and endosomes.
Part 4: Poster session 2 was held in the afternoon (for 1 ½ hours). Thereafter, the NAS General Assembly, which is open to all NAS members, was held by the NAS chair Nikolai Engedal. The history and current status of NAS was presented, the NAS Board was re-elected with a new recruitment for Norway (Helene Knævelsrud) and two new recruitments for the Netherlands (Kasper Rouschop and Mario Mauthe), and the location and tentative dates of next year’s Conference were decided (see the bottom of this page for info on that). Day 2 concluded with the Conference Dinner at the hotel, followed by socializing in the lobby area and/or a refreshing walk outside with failed attempts from some participants (no names disclosed) to see Northern Lights (they tried hard, but eventually had to conclude that it was too cloudy that night).
Part 1: The third and final day of the Conference featured the 4th Keynote Lecture, where Patricia Boya (CIB Margarita Salas, Madrid, Spain) presented intriguing data on the relationship between autophagy and age-associated retinal defects. This was followed by a short talk on a novel mechanism of autophagic clearance of amyloid aggregates.
Part 2: The scientific part of the Conference was wrapped up by short talks on autophagy-related proteins in virus infection, and virus-induced escape of xenophagy. Thereafter, all participants could vote for the best short talk (one prize sponsored by the NAS-affiliated MDPI journal “Cells”) and the best posters (3 prizes sponsored by the journal “Traffic” and 1 prize sponsored by the newly established journal “Autophagy Reports”). The prize ceremony saw Simona Migliano (Oslo University Hospital, Norway) win the best short talk award, whereas the best poster awards where won by Lauren Johnson and Rodriguez de la Ballina (University of Oslo, Norway), Aida Rodríguez López (The Danish Cancer Society), Nikoline Lander Rasmussen (UiT – the Arctic University of Norway), and Thorbjørn Marciniak Nielsen (The Danish Cancer Society).
Best Short Talk and Best Posters Awards!
From left to right: Nikolai Engedal, Terje Johansen, Best Short Talk winner Simona Migliano (Oslo University Hospital, Norway), and the best poster award winners Thorbjørn Marciniak Nielsen (The Danish Cancer Society), Nikoline Lander Rasmussen (UiT – the Arctic University of Norway), Aida Rodríguez López (The Danish Cancer Society), and Lauren Johnson and Rodriguez de la Ballina (University of Oslo, Norway).
Part 3: The Conference ended with concluding remarks and a thank you to all the people who made the Meeting happen: Nikolai Engedal (Organizer, Conference and NAS chair), Terje Johansen (Local organizer and Conference chair), Gry Evjen (Local organizer committee leader), Eva Sjøttem and Trond Lamark (Local organizing committee), Terje Johnsen’s group members for technical and practical assistance, the NAS Board for scientific advice, the NAS web masters Behzad Khoshnood and Rubén Gómez-Sánchez for web and registration help, the NAS treasurer Anu Kauppinen, the NAS sponsorship team (Nikolai Engedal, Daniel Hofius, Chara Charsou, Karolina Pircs, Merve Kacal), the invited Speakers (Ian Ganley, Nick Ktistakis, Marja Jäättelä, Patricia Boya), and the Sponsors (UiT – the Arctic University of Norway, Silver Sponsor Nordic Biosite, The Dutch Research Council (NWO), Dojindo, Cells, Traffic, and Autophagy Reports)…
…and finally, a great thanks to all the participants for their good spirits and active participation!
Thanks to all 109 participants at the 4th NAS Conference in Tromsø !
NOTE: The 5th Nordic Autophagy Society Conference / 10th Nordic Autophagy Meeting will be held in Denmark, with tentative dates September 14.-16. 2022.
The MDPI journal Cells is preparing a special issue on Autophagy and RNA. Send in your contributions and get a 50% discount as a NAS member.
More information at: https://www.mdpi.com/journal/cells/special_issues/Autophagy_RNA
NAS affiliated with the MDPI Journal Cells
NAS recently signed an affiliation agreement with the MDPI Journal Cells.
Cells is published in open access model, which means:
• everyone has free and unlimited access to the full‐text of all articles published in the journal.
• everyone is free to re‐use the published material if proper accreditation/citation of the original
publication is given.
• the authors retain the copyright of their work instead of transferring it to the publisher.
• open access publications are supported by article processing charges paid by the authors
MDPI journals, including Cells, have very reasonable article processing charges (APCs) compared with other journals in the field (see where MDPI is placed in terms of mean value of APC in 2019 here).
Advantages for NAS members:
– All NAS members will receive a 15% discount* on the article processing charges. The APC for Cells in 2020 is 2000 CHF (Swiss Francs), i.e. as a NAS member, you will get a 300 CHF discount (thus the APC will be 1700 CHF for NAS members).
* If authors’ institutions are part of the MDPI Institutional Open Access Program and already enjoy a discount, the highest discount will apply.
– NAS will be granted 2 waivers per year that may be used for any of the regular papers submitted by members of the society. The waivers will preferentially be given to papers authored by NAS members from at least two different NAS membership countries (Norway, Sweden, Finland, Denmark, Iceland, Estonia, Latvia, Lithuania, and the Netherlands) resulting from collaborative efforts. To apply for a waiver, please contact the NAS Board.
– Sciforum.net platform for organizing society conferences and conference organizing services at preferential rates. The NAS as well as each of its members will be able to use the platform free of charge if self‐managed.
-February 19th, 2020
NEW! For Companies: Do you want to advertise on our home page?
The NAS has decided to open its home page to companies or private sponsors to advertise their products and services, targeting directly the Nordic Autophagy Society members and our visitors. Advertisements will be published on a first come first served basis. Advertisement banners are available at two locations on the home page as follow:
Sponsor I (top right location – currently the autophagosome)
Top location is a stationary advertisement containing a hyperlink to the company’s webpage of choice. Banner maximum size: 500 (h) x 500 (w)
€100 per week
Sponsor II (bottom left location) and Sponsor III (bottom right location) – currently Logos
Those ads are shown as slide show: 8 seconds per show, containing a hyperlink to the company’s webpage of choice. The slide shows starts at random in the series of advertisements, ensuring that all advertisements have an equal chance of being shown. Banner maximum size: 200 (h) x 500 (w)
€50 per week